Journal Articles – Dr Galkin's lab

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Jabůrek M, Průchová P, Holendová B, Galkin A, Ježek P.

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid-Conducting SLC25 Gene Family Transporters Antioxidants PDF

DOI: 10.3390/antiox10050678

Sosunov SA, Niatsetskaya ZV, Stepanova AA, Galkin AS, Juliano CE, Ratner VI, Ten VS.

Developmental window of vulnerability to white matter injury driven by sublethal intermittent hypoxemia Pediatric Research PDF

DOI: 10.1038/s41390-021-01555-x

Nihori M, Eccles CA, Kurdyukov S, Zemskova M, Varghese MV, Stepanova AA, Galkin A, Rafikov R, Rafikova O.

Rats with Human Mutation of NFU1 Develop Pulmonary Hypertension American Journal of Respiratory Cell and Molecular Biology PDF

DOI: 10.1165/rcmb.2019-0065OC

Stepanova A, Galkin A.

Measurement of mitochondrial H2O2 production under varying O2 tensions Methods in Cell Biology 155, 273-293. PDF

DOI: 10.1016/bs.mcb.2019.12.008

Schlegel A, Muller X, Mueller M, Stepanova A, Kron P, de Rougemont O, Muiesan P, Clavien PA, Galkin A, Meierhofer D, Dutkowski P.

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation EBioMedicine 2020 PDF

DOI: 10.1016/j.ebiom.2020.103014

Niatsetskaya Z, Sosunov S, Stepanova A, Goldman J, Galkin A, Neginskaya M, Pavlov E, Ten V.

Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury Journal of Clinical Investigation PDF

DOI: 10.1172/JCI133082

Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O’Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E.

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice Communications Biology 4, 61. PDF

DOI: 10.1038/s42003-020-01584-y

Galkin A.

Water route for proton pumping in mitochondrial complex I Nature Structural & Molecular Biology PDF

DOI: 10.1038/s41594-020-0500-y

Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A.

Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain Journal of Cerebral Blood Flow & Metabolism 271678X18770331. PDF

DOI: 10.1177/0271678X18770331

Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A.

The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A Journal of Neurochemistry 148, 731-745. PDF

DOI: 10.1111/jnc.14654

Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A.

Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury Antioxidants & Redox Signaling 31, 608-622. PDF

DOI: 10.1089/ars.2018.7693

Hayes L, Asressa S, Li Y, Galkin A, Stepanova A, Kawamata H, Manfredi G, Glass J.

Distal denervation in the SOD1 knockout mouse correlates with loss of mitochondria at the motor nerve terminal Experimental Neurology 318, 251-257. PDF

DOI: 10.1016/j.expneurol.2019.05.008

Wojtovich AP, Berry BJ, Galkin A.

Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease Antioxidants & Redox Signaling 31, 591-593 PDF

DOI: 10.1089/ars.2019.7804

Ten V and Galkin A.

Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis Molecular and Cellular Neuroscience 100, 103408. PDF

DOI: 10.1016/j.mcn.2019.103408

Galkin A.

Brain Ischemia/Reperfusion Injury and Mitochondrial Complex I Damage Biochemistry 84, 1411-1423. PDF

DOI: 10.1134/S0006297919110154

Sahni PV, Zhang J, Sosunov S, Galkin A, Niatsetskaya Z, Starkov A, Brookes PS, Ten VS.

Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice Pediatric Research 83, 491-497. PDF

DOI: 10.1038/pr.2017.277

Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A.

Critical role of flavin and glutathione in Complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury Stroke 49, 223-1231. PDF

DOI: 10.1161/STROKEAHA.117.019687

Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten V.

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury Free Radical Biology and Medicine 124, 517-524. PDF

DOI: 10.1016/j.freeradbiomed.2018.06.040

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK.

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation Cell Metabolism PDF

DOI: 10.1016/j.cmet.2019.07.006

Dröse, S., Stepanova A., Galkin A.

Ischemic A/D transition of mitochondrial complex I and its role in ROS generation Biochimica et Biophysica Acta 1857, 946-957. PDF

DOI: 10.1016/j.bbabio.2015.12.013

Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A.

Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart Biochimica et Biophysica Acta 1857:1561-1568. PDF

DOI: 10.1016/j.bbabio.2016.06.002

Galkin A., Moncada S.

Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention Interface Focus 7:20160104. PDF

DOI: 10.1098/rsfs.2016.0104

Kiprowska M.J., Stepanova A., Todaro D.R., Galkin A., Haas A., Wilson S.M., Figueiredo-Pereira M.E.

Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: relevance to Alzheimer’s disease Biochimica et Biophysica Acta 1863:1157-1170. PDF

DOI: 10.1016/j.bbadis.2017.03.017

Suslova TA, Burmistrova AL, Vavilov MN, Chernova MS, Khromova EB, Belyaeva SV, Zaripova ON, Stashkevich DS, Galkin A, Darke C.

HLA gene and haplotype frequencies in a Nagaybaks population from the Chelyabinsk Region (Russian South Urals) Human Immunology 78:595-601. PDF

DOI: 10.1016/j.humimm.2017.08.005

Valsecchi F, Konrad C, D’Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J, Levin LR, Manfredi G.

Distinct intracellular sAC-cAMP domains regulate ER calcium signaling and OXPHOS function Journal of Cell Science 130:3713-3727. PDF

DOI: 10.1242/jcs.206318

Lin H, Magrane J, Rattelle A, Stepanova A, Galkin A, Clark E, Dong Y, M. Halawani S, Lynch D.

Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia Disease Models & Mechanisms 10:1343-1352. PDF

DOI: 10.1242/dmm.030502

Stepanova, A., Kahl, A., Konrad, C., Ten, V., Starkov, A, Galkin, A.

Reverse electron transfer results in a loss of flavin from mitochondrial complex I. Potential mechanism for brain ischemia/reperfusion injury Journal of Cerebral Blood Flow & Metabolism 271678 X 17730242. PDF

DOI: 10.1177/0271678X17730242

Sansone P, Savini C, Kurelac I, Chang Q, Amato L, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L, Galkin A, Thakur B, Soplop N, Uryu K, Hoshino A, Norton L, Bonafe M, Cricca M, Gasparre G, Lyden D, Bromberg J.

Packaging and transfer of mtDNA via exosomes regulate escape from dormancy in hormonal therapy resistant breast cancer Proceedings of the National Academy of Sciences of the United States of America 114:E9066-E9075. PDF

DOI: 10.1073/pnas.1704862114

Babot M., Labarbuta P., Birch A., Galkin A.

Characterisation of the active/deactive transition of mitochondrial complex I Biochimica et Biophysica Acta 1837:1083-1092. PDF

DOI: 10.1016/j.bbabio.2014.02.018

Babot M., Labarbuta P., Birch A., Kew S., Fuszard M., Botting C., Heide H., Wittig I., Galkin A.

ND3, ND1 and 39 kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I Biochimica et Biophysica Acta 1837:929-939. PDF

DOI: 10.1016/j.bbabio.2014.02.013

Glebova K., Reznik O., Reznik A., Mehta R., Galkin A., Baranova A., Skoblov M.

A potential of siRNA technology in kidney transplantation BioDrugs 28:345-361. PDF

DOI: 10.1007/s40259-014-0087-0

Stepanova A., Valls A., Galkin A.

Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I Biochimica et Biophysica Acta 1847:1085–1092. PDF

DOI: 10.1016/j.bbabio.2015.05.012

Hyspler R., Ticha A., Schierbeek H., Galkin A., Zadak Z.

The evaluation and quantitation of dihydrogen metabolism using deuterium isotope in rats PLOS One 10:e0130687. PDF

DOI: 10.1371/journal.pone.0130687

Carey N., Galkin A., Henriksson P., Richards J.G., Sigwart J.D.

Variation in oxygen consumption among ‘living fossils’ (Mollusca: Polyplacophora) Journal of the Marine Biological Association of the United Kingdom 93, 197–207. PDF

DOI: https://doi.org/10.1017/S0025315412000653[Opens in a new window]

Gorenkova N., Robinson E., Grieve D., Galkin A.

Conformational change of mitochondrial complex I increases ROS sensitivity during ischaemia Antioxidants & Redox Signaling 19, 1459-68. PDF

DOI: 10.1089/ars.2012.4698

Ciano M., Fuszard M., Heide H., Botting C.H., Galkin A.

Conformation-specific crosslinking of mitochondrial complex I FEBS Letters 587:867-872. PDF

DOI: 10.1016/j.febslet.2013.02.039

Babot M., Galkin A.

Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I Biochemical Society Transactions 41:1325-1330. PDF

DOI: 10.1042/BST20130088

Gostimskaya I., Galkin A.

Preparation of Highly Coupled Rat Heart Mitochondria Journal of Visualized Experiments PDF

DOI: 10.3791/2202

Galkin, A., Zwicker, K., Dröse, S., Grgic, L., Kerscher, S. and Brandt, U.

The redox-Bohr group associated with iron-sulfur cluster N2 of complex I Journal of Biological Chemistry 281:23013-23017. PDF

DOI: 10.1074/jbc.M603442200

Galkin, A., Dröse, S., Brandt, U.

The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes Biochimica et Biophysica Acta 1757:1575-1581. PDF

DOI: 10.1016/j.bbabio.2006.10.001

Galkin, A., Higgs, A., Moncada, S.

Nitric oxide and hypoxia Essays in Biochemistry 43: 29-40. PDF

DOI: 10.1042/BSE0430029

Galkin, A. and Moncada, S.

Nitrosation of mitochondrial complex I Journal of Biological Chemistry 282: 37448-37453. PDF

DOI: 10.1074/jbc.M707543200

Galkin, A., Meyer, B., Wittig, I., Karas, M., Schägger H., Vinogradov, A., Brandt, U.

Identification of the mitochondrial complex I ND3 subunit as a structural component involved in the active/de-active enzyme transition Journal of Biological Chemistry 283: 20907-20913. PDF

DOI: 10.1074/jbc.M803190200

Drose S., Galkin A., Brandt, U.

Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica Methods in Enzymology 456: 475-490. PDF

DOI: 10.1016/S0076-6879(08)04426-1

Galkin, A., Abramov, A., Frakich, N., Duchen, M., Moncada, S.

Lack of oxygen deactivates mitochondrial complex I: Implications for ischemic injury? Journal of Biological Chemistry 284: 36055-36061. PDF

DOI: 10.1074/jbc.M109.054346

Galkin, A., Grivennikova, V.G., Vinogradov, A.D.

Stoichiometry of the NADH:Ubiquinone reductase reaction catalyzed by mitochondrial Complex I Biochemistry (Moscow) 66:435-537. PDF

DOI: 10.1023/a:1010257630935

Finikova O., Galkin, A., Cordero, M., Hägerhäll, C., Vinogradov, S.

Dendritic porphyrins and tetrabenzoporphyrins: tunable membrane-impermeable fluorescent pH sensors Journal of the American Chemical Society 125:4882 – 4893. PDF

DOI: 10.1021/ja0341687

Eschemann A., Galkin, A., Oettmeier, W., Brandt, U., Kerscher, S.

HDQ (1-hydroxy-2-dodecyl-4(1H)-quinolone), a high affinity inhibitor for mitochondrial alternative NADH-dehydrogenase – evidence for a ping-pong mechanism Journal of Biological Chemistry 280:3138-3142. PDF

DOI: 10.1074/jbc.M411217200

Brandt, U., Abdrakhmanova, A., Zickermann, V., Galkin, A., Dröse, S., Zwicker, K., Kerscher, S.

Structure-function relationship in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica Biochemical Society Transactions 33:840-844. PDF

DOI: 10.1042/BST0330840

Galkin, A. and Brandt, U.

Superoxide radical formation by pure complex I (NADH: Ubiquinone oxidoreductase) from Yarrowia lipolytica Journal of Biological Chemistry 280:30129-30135. PDF

DOI: 10.1074/jbc.M504709200

Dröse, S., Galkin, A., Brandt, U.

Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes Biochimica et Biophysica Acta 1710:87-95. PDF

DOI: 10.1016/j.bbabio.2005.10.001

Galkin, A., Grivennikova, V.G., Vinogradov, A.D.

Stoichiometry in NADH-quinone reductase reactions catalyzed by the bovine heart submitochondrial particles FEBS Letters 451:157-161. PDF

DOI: 10.1016/s0014-5793(99)00575-x